Saginaw Trail is the collective name for a set of connected roads in Southeast and Central Michigan that runs from Detroit to Saginaw through Pontiac and Flint that was originally a tribal foot trail. To drive it today, drivers would follow: from Detroit to Birmingham; Old Woodward Avenue through Birmingham; from Birmingham to Pontiac; into downtown Pontiac; Former routing of Saginaw Street through downtown within the Woodward Avenue Loop; north of the Woodward Avenue Loop; north of Pontiac to Clarkston; Dixie Highway, a set of various county roads that were previously US 10 from Clarkston to near Grand Blanc; Saginaw Road and Saginaw Street through Grand Blanc, Burton, and Flint to north of Mount Morris; from north of Mount Morris near Clio to the Genesee–Saginaw County line; Dixie Highway and Genesee Avenue into Saginaw.

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