SFN may refer to:
Short filename, the 8.3 filename limitation of the DOS computer operating system SFN Group, Inc., a North American temporary work agency Single-frequency network, a broadcast network where several transmitters simultaneously send the same signal over the same frequency channel Small fiber neuropathy Society for Neuroscience, a professional society headquartered in Washington, D.C. Subcutaneous fat necrosis of the newborn, a medical condition occurring in newborns Protein stratifin