Mercedes of Spain may refer to:
Mercedes of Orléans, (1860–1878) queen of Spain in 1878 as the wife of Alfonso XII Mercedes, Princess of Asturias, (1880–1904) eldest daughter of Alfonso XII; heiress presumptive to the throne for her whole life Infanta María de las Mercedes of Spain, (1911–1953) daughter of Infanta Maria Teresa and granddaughter of Alfonso XII Princess Maria de las Mercedes of Bourbon-Two Sicilies, Countess of Barcelona, mother of Juan Carlos I