Mahfouz is a surname. Notable people with the name include:
Khalid bin Mahfouz (1949–2009), Saudi businessman Naguib Mahfouz (1911-2006), Nobel Prize–winning Egyptian novelist Naguib Pasha Mahfouz (1882–1974), Egyptian obstetrician and gynecologist Sabir Mahfouz Lahmar, Algerian-born naturalised Bosnian citizen detained by the United States in Guantanamo Bay, Cuba from 2002 to 2009
See also Mahfuz, a given name